Clinical Trials at ONJCRI

Clinical trials are research studies conducted with patients to evaluate new medical treatments, interventions, or tests. These trials are essential for developing innovative treatments and improving patient outcomes. Without clinical trials, advancements in medicine would be nearly impossible. They ensure that new therapies are safe, effective, and ultimately beneficial for the public.

Clinical trials are carefully designed research studies that test new ways to prevent, detect, or treat diseases. They involve several phases:

• Phase I trials test the safety of a new treatment in a small group of people.
• Phase II trials expand the study to more people to evaluate its effectiveness and further assess safety.
• Phase III trials compare the new treatment against the current standard treatment in large groups of patients to confirm its effectiveness, monitor side effects, and collect information that will allow the treatment to be used safely.
• Phase IV trials take place after the treatment has been approved for use by the general public, focusing on long-term effects and benefits.

Each phase is crucial to ensuring that new treatments are not only effective but also safe for patients. Clinical trials are the backbone of medical advancements, leading to the development of new, improved therapies and better quality of life for patients.

Clinical trials bring numerous benefits to society, including:

• Innovative Treatments: They provide access to new treatments that are not yet available to the public.
• Improved Outcomes: By testing new treatments, researchers can find more effective therapies that improve survival rates and quality of life.
• Scientific Advancement: Trials contribute to scientific knowledge, helping to understand diseases better and how to treat them.
• Patient Safety: Rigorous testing ensures that new treatments are safe for patients.
• Economic Benefits: Successful trials can lead to new drugs and therapies, fostering economic growth and job creation in the healthcare sector.

The Olivia Newton-John Cancer Research Institute (ONJCRI) is at the forefront of conducting impactful clinical trials. Their work has led to significant advancements in cancer treatment, demonstrating the critical role of clinical trials in medical research. 

Here are a few examples of ONJCRI's achievements in this area:

• TOP-FLOR Clinical Trial: The TOP-FLOR trial focuses on Follicular Lymphoma (FL), a slow-growing blood cancer. This Phase II trial tests the combination of rituximab and golcadomide with or without nivolumab, aiming to reduce treatment side effects and improve long-term effectiveness. Such trials are crucial in finding better treatments for FL patients and improving their quality of life.

• MoST-CIRCUIT Clinical Trial: The MoST-CIRCUIT trial addresses rare cancers, which often have limited treatment options. By exploring the combination of nivolumab and ipilimumab, this Phase II study aims to extend survival and improve outcomes for patients with immunotherapy-sensitive rare cancers. This trial exemplifies how clinical trials can provide new hope for patients with few existing options.

• VADER Clinical Trial: The VADER trial targets metastatic colorectal cancer, a leading cause of cancer death. This trial investigates the combination of sodium valproate, traditionally used for epilepsy, with EGFR monoclonal antibodies as a maintenance therapy. By repurposing existing drugs, this trial seeks to find new, effective treatments for advanced bowel cancer, highlighting the innovative approach of ONJCRI.

ONJCRI's clinical trials are a beacon of hope for many cancer patients. Their research not only seeks to improve survival rates but also aims to enhance the quality of life for those battling cancer. At Anticancer, we are committed to supporting ONJCRI's mission. Your donations via Anticancer will fund these critical clinical trials, helping to bring new treatments from the lab to the bedside.

Together, we can make a significant impact. Support ONJCRI through Anticancer and be a part of the fight against cancer. Every contribution brings us one step closer to a cure. Donate today and help us turn the tide against cancer.